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Hideaki Tomura Selected Research

Protons (Proton)

1/2021Metal-Stimulated Interleukin-6 Production Through a Proton-Sensing Receptor, Ovarian Cancer G Protein-Coupled Receptor 1, in Human Bronchial Smooth Muscle Cells: A Response Inhibited by Dexamethasone.
10/2020The protective role of proton-sensing TDAG8 in the brain injury in a mouse ischemia reperfusion model.
4/2020Involvement of GPR4 in increased growth hormone and prolactin expressions by extracellular acidification in MtT/S cells.
10/2019Characterization of molecular mechanisms of extracellular acidification-induced intracellular Ca2+ increase in LβT2 cells.
4/2018Metals Differentially Activate Ovarian Cancer G Protein-Coupled Receptor 1 in Various Species.
1/2013Proton-sensing ovarian cancer G protein-coupled receptor 1 on dendritic cells is required for airway responses in a murine asthma model.
11/2012Ovarian cancer G-protein-coupled receptor 1 induces the expression of the pain mediator prostaglandin E2 in response to an acidic extracellular environment in human osteoblast-like cells.
9/2012Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion.
10/2011Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in human airway smooth muscle cells.
9/2010Ovarian cancer G protein-coupled receptor 1-dependent and -independent vascular actions to acidic pH in human aortic smooth muscle cells.
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Hideaki Tomura Research Topics

Disease

17Ovarian Neoplasms (Ovarian Cancer)
10/2022 - 10/2004
4Neoplasms (Cancer)
04/2020 - 02/2004
4Pancreatic Neoplasms (Pancreatic Cancer)
06/2012 - 01/2002
4Atherosclerosis
09/2010 - 07/2003
3Ascites
06/2012 - 02/2004
3Glioma (Gliomas)
12/2009 - 10/2005
2Asthma (Bronchial Asthma)
01/2013 - 10/2010
2Neoplasm Metastasis (Metastasis)
11/2012 - 06/2012
2Type 2 Diabetes Mellitus (MODY)
06/2011 - 11/2008
2Inflammation (Inflammations)
10/2010 - 09/2010
2Rheumatoid Arthritis
11/2008 - 10/2008
1Leukemia
10/2022
1Occupational Asthma
01/2021
1Cerebral Infarction
10/2020
1Ischemia
10/2020
1Brain Injuries (Brain Injury)
10/2020
1Hyperpituitarism
04/2020
1Pituitary Neoplasms (Pituitary Adenoma)
04/2020
1Eosinophilia
01/2013
1Metaplasia
01/2013
1Respiratory Hypersensitivity
01/2013
1Osteoporosis
11/2012
1Pain (Aches)
11/2012
1Glucose Intolerance
09/2012
1Insulin Resistance
09/2012
1Airway Remodeling
10/2011
1Hypoglycemia (Reactive Hypoglycemia)
06/2011
1Immune System Diseases (Immune Disorders)
11/2008
1Acidosis
07/2008
1Glioblastoma (Glioblastoma Multiforme)
02/2008
1Astrocytoma (Pilocytic Astrocytoma)
02/2008
1Cardiovascular Diseases (Cardiovascular Disease)
10/2006
1Obesity
11/2004

Drug/Important Bio-Agent (IBA)

18G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
10/2022 - 10/2004
14Protons (Proton)IBA
01/2021 - 10/2004
7lysophosphatidic acidIBA
06/2012 - 02/2004
4Proteins (Proteins, Gene)FDA Link
01/2021 - 02/2008
4Small Interfering RNA (siRNA)IBA
11/2012 - 02/2004
3CytokinesIBA
01/2021 - 02/2004
3Lysophosphatidic Acid ReceptorsIBA
06/2012 - 02/2004
3LipidsIBA
09/2010 - 02/2004
3HDL LipoproteinsIBA
11/2008 - 07/2003
3Inositol PhosphatesIBA
10/2005 - 10/2004
2CobaltIBA
01/2021 - 08/2017
2Glucose (Dextrose)FDA LinkGeneric
09/2012 - 06/2011
2TensinsIBA
12/2009 - 02/2008
2Phosphoric Monoester Hydrolases (Phosphatases)IBA
12/2009 - 02/2008
23- (4- (4- ((1- (2- chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acidIBA
03/2009 - 02/2004
2sphingosine 1-phosphate (sphingosine-1-phosphate)IBA
02/2008 - 10/2005
1Edetic Acid (EDTA)FDA Link
10/2022
1MetalsIBA
01/2021
1Dexamethasone (Maxidex)FDA LinkGeneric
01/2021
1Interleukin-6 (Interleukin 6)IBA
01/2021
1NickelIBA
01/2021
1Minocycline (Cyclops)FDA LinkGeneric
10/2020
1Lactic Acid (Lactate)FDA LinkGeneric
04/2020
1Growth Hormone (Somatotropin)IBA
04/2020
1ProlactinIBA
04/2020
1Hormones (Hormone)IBA
04/2020
1ogerinIBA
04/2020
1ManganeseIBA
08/2017
1Immunoglobulin E (IgE)IBA
01/2013
1OvalbuminIBA
01/2013
1GTP-Binding Proteins (G-Protein)IBA
01/2013
1Dinoprostone (PGE2)FDA Link
11/2012
1Glucagon (Glukagon)FDA Link
09/2012
13- (4- (4- ((1- (2- chlorophenyl)ethoxy)carbonylamino)- 3- methyl- 5- isoxazolyl)benzylsulfanyl)propanoic acid methyl esterIBA
06/2012
1Matrix Metalloproteinases (MMPs)IBA
06/2012
1Extracellular Matrix ProteinsIBA
10/2011
1Connective Tissue Growth FactorIBA
10/2011
1YM-254890IBA
10/2011
1Insulin (Novolin)FDA Link
06/2011
1Blood Glucose (Blood Sugar)IBA
06/2011
1Heat-Shock Proteins (Heat-Shock Protein)IBA
06/2011
1Chemokine CCL5IBA
10/2010
1Chemotactic FactorsIBA
10/2010
1ChemokinesIBA
10/2010
1Plasminogen InactivatorsIBA
09/2010
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
09/2010
1ProstaglandinsIBA
09/2010
1Dual Specificity Phosphatase 1IBA
09/2010
1Cyclic AMP Receptors (Cyclic AMP Receptor)IBA
12/2009
1erythromycin propionate-N-acetylcysteinateIBA
12/2009
1Isoproterenol (Isoprenaline)FDA LinkGeneric
12/2009
1Pertussis ToxinIBA
03/2009
1Epidermal Growth Factor (EGF)IBA
03/2009
1Lipoproteins (Lipoprotein)IBA
11/2008
1Biomarkers (Surrogate Marker)IBA
11/2008
1Mutant Proteins (Protein, Mutant)IBA
11/2008
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
10/2008
1CalciumIBA
07/2008
1Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
10/2006
1MitogensIBA
10/2005
1Phosphotransferases (Kinase)IBA
10/2005
1sphingosine phosphorylcholineIBA
10/2005
1Type C PhospholipasesIBA
10/2005
1Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
11/2004
1Hepatocyte Nuclear FactorsIBA
11/2004
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
02/2004

Therapy/Procedure

1Oral Administration
06/2012